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[Elevated plasma homocysteine and glutathione level in patients with renal failure]

R V Golubev, E L Blashko, V A Dobronravov

    Biomeditsinskaia Khimiia
    |December 14, 2005
    PubMed

    Insights

    Homocysteine (Hcy) levels increase with chronic kidney disease (CKD) progression, particularly in hemodialysis patients. Glutathione (Glt) levels decrease in dialysis patients, showing complex interactions with Hcy and kidney function.

    Area of Science:

    • Biochemistry
    • Nephrology
    • Clinical Chemistry

    Context:

    • Chronic kidney disease (CKD) affects numerous patients globally.
    • Biochemical markers like homocysteine (Hcy) and glutathione (Glt) play crucial roles in metabolic processes.
    • Understanding these markers' behavior in CKD is vital for patient management.

    Purpose:

    • To investigate plasma levels of homocysteine (Hcy) and glutathione (Glt) in patients with varying stages of chronic kidney disease (CKD).
    • To analyze the relationship between Hcy and Glt levels and the severity of kidney dysfunction, including glomerular filtration rate (GFR).
    • To compare these biochemical markers between predialysis and hemodialysis patient groups.

    Summary:

    • Elevated plasma homocysteine (Hcy) was observed even in early stages of CKD, escalating significantly in hemodialysis patients.
    • Total and reduced Hcy (tHcy, rHcy) levels were higher in CKD patients, with a greater proportion of rHcy compared to healthy subjects.
    • A negative correlation between GFR and Hcy was found in predialysis patients. Glutathione (Glt) levels were lower in dialysis patients than predialysis patients, with a direct dependence on tHcy in the predialysis group.

    Impact:

    • Findings highlight Hcy as a potential biomarker for CKD progression and severity.
    • The study provides insights into the altered redox balance in CKD patients.
    • Results may inform future therapeutic strategies targeting Hcy and Glt metabolism in kidney disease.

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