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Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and

O Mayer1, J Simon, L Holubec

  • 1Second Department of Internal Medicine, Charles University, Plzen, Czech Republic. mayerjr@lfp.cuni.cz

Physiological Research
|December 14, 2005
PubMed
Summary
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Fibrate therapy increases homocysteine (tHcy), potentially harming blood vessels. Folate co-administration with fenofibrate improved lipid profiles and reduced oxidative stress markers, unlike fenofibrate alone.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Fibrate therapy can elevate plasma total homocysteine (tHcy).
  • Elevated tHcy is linked to oxidative stress and endothelial dysfunction.
  • The impact of fibrate-induced tHcy elevation and potential prevention by folate require investigation.

Purpose of the Study:

  • To determine if fenofibrate-induced tHcy elevation causes oxidative stress and endothelial dysfunction.
  • To assess if folate co-administration can prevent these adverse effects.
  • To compare fenofibrate's effects with fluvastatin therapy.

Main Methods:

  • Open, prospective, cross-over study involving 18 hypercholesterolemic subjects.
  • Intra-individual comparison of fenofibrate monotherapy versus fenofibrate plus folate (10 mg).

Related Experiment Videos

  • Comparison with fluvastatin (80 mg) monotherapy, assessing tHcy, oxidative stress, and endothelial dysfunction markers.

    • Main Results:

    • Fenofibrate monotherapy increased tHcy by 39.5% but did not alter oxidative stress markers (oxLDL, MDA) or endothelial markers (vWf, TMD).
    • Fenofibrate with folate maintained tHcy levels and decreased total/oxLDL, MDA, vWf, and TMD.
    • Fluvastatin monotherapy did not influence tHcy and showed effects similar to combined fenofibrate-folate therapy.

    Conclusions:

    • Fenofibrate reduces LDL cholesterol but lacks antioxidative and endothelium-protective effects, possibly due to increased tHcy.
    • Flustered monotherapy appears to have a more favorable profile regarding oxidative stress and endothelial function.
    • Co-administration of folate with fenofibrate may mitigate adverse effects and enhance cardiovascular protection.