Related Experiment Video
Updated: Aug 14, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Concomitant hairy cell and acute myeloid leukemia
1Division of Hematology, University Hospital Basel, Basel, Switzerland.
European Journal of Haematology
|December 14, 2005
Summary
This case study presents a rare instance of a patient diagnosed with both acute myeloid leukemia (AML) and hairy cell leukemia (HCL) simultaneously. The simultaneous occurrence suggests a potential genetic link rather than treatment side effects.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Secondary malignancies are documented in hairy cell leukemia (HCL) patients, often linked to treatments.
- The role of purine analog therapy in secondary cancers is a known concern.
Observation:
- A 58-year-old patient presented with concurrent diagnoses of acute myeloid leukemia (AML) and HCL.
- Initial treatment involved cladribine, daunorubicin, cytosine arabinoside, and autologous stem cell transplantation.
Findings:
- The patient achieved complete remission of AML and hematologic remission of HCL for 22 months.
- A subsequent relapse with AML occurred after the initial remission period.
Implications:
- The simultaneous presentation of AML and HCL suggests a potential underlying genetic predisposition.
- This case challenges the assumption that such concurrent diagnoses are solely related to prior HCL treatments or purine analogs.
Related Concept Videos
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...