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Updated: Aug 14, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Multiallelic selection polymorphism
1Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, IL 60637, USA. choman@uchicago.edu
Abstract:
The existence and stability of an internal (i.e., completely polymorphic) equilibrium for viability selection at a single multiallelic locus is investigated. Generations are discrete and nonoverlapping; the population is panmictic, monoecious, and diploid. Various necessary and sufficient conditions for the existence of an internal equilibrium are established and applied to the loss of alleles. Some necessary conditions for the existence of an asymptotically stable internal equilibrium are also established. All these conditions are simpler and yield general biological conclusions more easily than the classical necessary and sufficient conditions.
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