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Published on: November 21, 2013
Diminished neurocardiac dynamics associated with antipsychotic-induced extrapyramidal syndrome
Jong-Hoon Kim1, Sang Hoon Yi, Kyung Tae Park
1Department of Psychiatry, Gil Medical Center, Gachon Medical School, Incheon, South Korea.
Abstract:
The relationship between antipsychotic-induced extrapyramidal syndrome (EPS) and the autonomic neurocardiac function was examined in 57 schizophrenic patients treated with atypical antipsychotics. Comprehensive assessments of EPS and heart rate dynamics were performed. There was a significant negative correlation of non-hypokinetic parkinsonism, akathisia, and dyskinesia with several linear and novel non-linear heart rate dynamics measures, suggesting reduced neurocardiac dynamics associated with some forms of EPS. Assessment of heart rate dynamics may be useful for the detection of these adverse effects and may serve as a useful non-invasive method providing a dynamic window into the alterations of complex neuronal activity.
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