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Updated: Aug 14, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
Published on: November 4, 2022
Pentraxins as a key component of innate immunity
Barbara Bottazzi1, Cecilia Garlanda, Giovanni Salvatori
1Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
Abstract:
Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
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