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Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism

E Martignoni1, M Cosentino, M Ferrari

  • 1Department of Clinical Medicine, University of Piemonte Orientale Amedeo Avogadro, Salvatore Maugeri Foundation, Scientific Institute of Veruno, Novara, Italy.

Neurology
|December 14, 2005
PubMed
Summary

Catechol-O-methyltransferase (COMT) inhibitor use in Parkinson disease patients can cause liver issues. Specific genetic mutations in UDP-glucuronosyltransferase (UGT) 1A9 may increase the risk of this drug-induced liver injury.

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