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Hepatic changes during short-term haemodialysis.

U S Rai1, R G Singh, Usha

  • 1IGIMS, Patna.

The Journal of the Association of Physicians of India
|January 1, 1992
PubMed
Summary
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End-stage renal disease patients undergoing short-term hemodialysis experienced significant biochemical and hepatic morphological changes. Liver biopsies revealed common abnormalities like fatty changes and hepatic congestion, indicating potential liver complications during dialysis.

Area of Science:

  • Nephrology
  • Hepatology
  • Pathology

Background:

  • End-stage renal disease (ESRD) necessitates renal replacement therapy, often hemodialysis.
  • Hemodialysis can lead to various systemic complications, including potential hepatic alterations.
  • Understanding these hepatic changes is crucial for patient management.

Purpose of the Study:

  • To investigate biochemical and hepatic morphological alterations in ESRD patients during short-term hemodialysis.
  • To identify the prevalence of specific liver abnormalities in this patient cohort.

Main Methods:

  • Studied twenty-five patients with end-stage renal disease undergoing short-term hemodialysis.
  • Assessed biochemical markers and performed liver biopsies for histopathological examination.

Related Experiment Videos

  • Documented clinical findings such as hepatomegaly and Australia antigen status.

    • Main Results:

    • Hepatomegaly observed in 32% of patients; elevated transaminases in 28%; positive Australia antigen in 12%.
    • All 12 patients with liver biopsies showed histopathological changes.
    • Multiple abnormalities were present in 82% of biopsied patients, with fatty change (67%), hepatic congestion (50%), focal necrosis (50%), Kupffer cell hyperplasia (50%), and portal triaditis (42%) being most frequent.

    Conclusions:

    • Short-term hemodialysis in ESRD patients is associated with significant biochemical and histopathological liver changes.
    • Fatty change, hepatic congestion, and focal necrosis are common findings.
    • Further research is warranted to elucidate the long-term implications and management strategies for dialysis-induced liver abnormalities.