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Platelet aggregation in migraine

S Jha1, M Varma, R Garg

  • 1Department of Neurology, King George's Medical College, Lucknow.

The Journal of the Association of Physicians of India
|March 1, 1992
PubMed

Insights

Migraine attacks involve increased platelet aggregation, particularly during aura and headache phases. This suggests platelet hyperaggregability plays a key role in migraine development.

Area of Science:

  • Neurology
  • Hematology

Background:

  • Migraine is a common neurological disorder.
  • The role of platelets in migraine pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate platelet aggregation levels in migraine patients during symptomatic and asymptomatic phases.

Main Methods:

  • Evaluated platelet aggregation in 40 male migraine patients aged 17-35.
  • Measurements were taken during migraine aura/headache and headache-free intervals.

Main Results:

  • Platelet aggregation was significantly higher during migraine attacks (aura and headache phases).
  • A notable increase in platelet aggregation was observed compared to asymptomatic periods.

Conclusions:

  • Platelet hyperaggregability is a significant finding in migraine patients.
  • This supports the hypothesis that platelet activity is crucial in the development of migraine.

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