Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medulloblastoma: II. A pathobiologic overview.

F H Tomlinson1, B W Scheithauer, R B Jenkins

  • 1Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905.

Journal of Child Neurology
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of leukemia inhibitory factor in craniopharyngioma.

Endocrine pathology·2016
Same author

Localization of vascular endothelial growth factor in nontumorous human pituitaries.

Endocrine pathology·2016
Same author

Invasive thymoma metastatic to the cavernous sinus.

Surgical neurology international·2013
Same author

Tumefactive demyelination and glioblastoma: a rare collision lesion.

Clinical neuropathology·2011
Same author

Dysembryoplastic neuroepithelial tumor and calcifying pseudoneoplasms of the neuraxis: a collision of two seizure-associated lesions.

Clinical neuropathology·2011
Same author

Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis.

Journal of neuro-oncology·2010
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
Same journal

Symptoms of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, and Autism Spectrum Disorder in Children and Adolescents Attending a Headache Outpatient Clinic and School-Based Controls.

Journal of child neurology·2026
Same journal

Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurology·2026
Same journal

The Cost of Fear for Pediatric Neurologic Care.

Journal of child neurology·2026
Same journal

Hospitalisation Experiences of Children with Neurological Illness: A Qualitative Exploration.

Journal of child neurology·2026
Same journal

The Burden of Idiopathic Developmental Intellectual Disability Attributed to Lead Exposure in Asian Children and Adolescents, 1990-2021: Trends, Inequalities, and Future Projections for the Global Burden of Disease Study 2021.

Journal of child neurology·2026
See all related articles

This review explores medulloblastoma's pathobiology, integrating immunocytochemical, cytobiologic, and molecular data. It clarifies its relationship with primitive neuroectodermal tumors and its classification within the central nervous system tumor hierarchy.

Area of Science:

  • Neuro-oncology
  • Molecular Pathology
  • Tumor Biology

Background:

  • Medulloblastoma is a primary brain tumor with complex origins.
  • Understanding its characteristics is crucial for accurate diagnosis and classification.
  • Evolving data necessitates a review of its pathobiology.

Purpose of the Study:

  • To review the pathobiology of medulloblastoma.
  • To integrate emerging immunocytochemical, cytobiologic, and molecular data.
  • To discuss its nosologic relationship with primitive neuroectodermal tumors and its WHO classification.

Main Methods:

  • Literature review of recent studies.
  • Analysis of immunocytochemical and cytobiologic data.
  • Integration of molecular biologic findings.

Related Experiment Videos

Main Results:

  • Medulloblastoma exhibits diverse immunocytochemical and cytobiologic profiles.
  • Molecular data provides deeper insights into medulloblastoma subtypes.
  • Clarification of its distinction from primitive neuroectodermal tumors.

Conclusions:

  • Medulloblastoma pathobiology is multifaceted, influenced by immunocytochemical, cytobiologic, and molecular factors.
  • Accurate classification, including its relation to primitive neuroectodermal tumors, is essential.
  • The World Health Organization classification provides a framework for understanding these tumors.