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Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes
A R Khokhar1, Q Xu, R A Newman
1Department of Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
Journal of Inorganic Biochemistry
|February 15, 1992
Abstract:
A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.