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Related Experiment Videos

Structural changes in the subcutaneous compartment in morbid obesity.

D T Janigan1, R Durning, B Perey

  • 1Department of Pathology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada.

Obesity Research
|September 1, 1993
PubMed
Summary

Subcutaneous fat lobules in morbid obesity show size variations and histological changes, potentially due to mechanical stresses within the abdominal wall. Further research is needed to understand these findings in obesity morphogenesis.

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Area of Science:

  • Obesity research
  • Adipose tissue biology
  • Pathologic anatomy

Background:

  • Morbid obesity involves excess fat accumulation in subcutaneous adipose tissue (SCC).
  • Fibroelastic septa within the SCC resist lobule expansion, influencing fat distribution.
  • Understanding SCC mechanics is crucial for obesity pathogenesis studies.

Purpose of the Study:

  • To examine pathological changes in the abdominal wall SCC of morbidly obese individuals after weight loss.
  • To investigate variations in adipose tissue lobule size and shape.
  • To explore potential correlations between lobule size, histological changes, and mechanical stresses.

Main Methods:

  • Pathologic examination of surgically excised abdominal wall SCC from 48 morbidly obese subjects post-gastroplasty.

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  • Macroscopic observation of lobule size and shape variations.
  • Light microscopy to assess septal integrity, elastic fibers, calcification, and adipocyte necrosis.

    • Main Results:

    • Adipose tissue lobules were large and exhibited notable variations in size and shape.
    • Incised SCC showed lobule bulging and septal retraction, indicating mechanical stress.
    • Histology revealed sparse disruptions of septal elastic fibers, calcification, and adipocyte necrosis.

    Conclusions:

    • Observed lobule variations and histological changes may result from mechanical stresses (compressional and tensile) within the SCC.
    • Findings suggest potential implications for understanding obesity morphogenesis and fat distribution.
    • Further studies are required to confirm these observations and compare them with non-obese and non-weight-loss populations.