Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymeric nanoparticle preparation that eradicates tumors.

Jason R McCarthy1, J Manuel Perez, Christian Brückner

  • 1MGH-Harvard Medical School, Center for Molecular Imaging Research, 149 13th Street, Room 5404, Charlestown, MA 02129, USA.

Nano Letters
|December 15, 2005
PubMed
Summary

We developed novel nanoparticles carrying a photosensitizer for targeted cancer therapy. These drug-eluting nanoparticles are safe in vivo and effectively kill cancer cells upon light activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epicardial Complement C3 Activation in Neonatal Cardiac Regeneration.

Circulation·2026
Same author

Structural Insight into ESI+-Generated Ions of Oxazolochlorin Derivatives Using Cryogenic Infrared Ion Spectroscopy.

Journal of the American Society for Mass Spectrometry·2025
Same author

Hierarchically Structured Stimuli-Responsive Liquid Crystalline Terpolymer-Rhodamine Dye Conjugates.

Molecules (Basel, Switzerland)·2025
Same author

Oxochlorin frameworks confining a β-hydroxyketone moiety.

Dalton transactions (Cambridge, England : 2003)·2024
Same author

Electronic Structures of an Annulated <i>meso</i>-Tetraphenylchlorin and a Related Chlorin Analogue Incorporating an 8-Membered Ring through MCD Spectroscopy and DFT Calculations.

The journal of physical chemistry. A·2024
Same author

Crystal structure of (6,9-diacetyl-5,10,15,20-tetra-phenyl-secochlorinato)nickel(II).

Acta crystallographica. Section E, Crystallographic communications·2024

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Photodynamic Therapy

Background:

  • Developing targeted cancer therapies remains a critical challenge.
  • Photosensitizers offer potential for cancer treatment but often lack specificity.
  • Nanoparticle drug delivery systems can improve therapeutic efficacy and reduce side effects.

Purpose of the Study:

  • To create stable poly(lactic-co-glycolic acid) nanoparticles encapsulating meso-tetraphenylporpholactol.
  • To evaluate the in vitro and in vivo efficacy of these nanoparticles for cancer treatment.
  • To demonstrate the selective phototoxicity of the released photosensitizer.

Main Methods:

  • Synthesis and characterization of poly(lactic-co-glycolic acid) nanoparticles.
  • Encapsulation of the photosensitizer meso-tetraphenylporpholactol.

Related Experiment Videos

  • In vitro studies on cancer cell lines assessing phototoxicity.
  • In vivo studies in mouse models to evaluate tumor eradication.

    • Main Results:

    • The nanoparticles were stable and nonphototoxic upon systemic administration.
    • Upon cellular uptake, the photosensitizer was released, inducing high phototoxicity.
    • Visible light irradiation led to cell-specific killing of various cancer cell lines.
    • Complete eradication of tumors was achieved in mouse models.

    Conclusions:

    • Meso-tetraphenylporpholactol-loaded nanoparticles demonstrate potent and selective phototoxicity against cancer cells.
    • This nanoparticle-based drug delivery system shows significant promise for effective cancer therapy.
    • The concept of photosensitizers with selective phototoxicity has broad applications in oncology.