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Related Experiment Videos

Working memory impairments in schizophrenia: a meta-analysis.

Junghee Lee1, Sohee Park

  • 1Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA. Junghee.Lee@vanderbilt.edu

Journal of Abnormal Psychology
|December 15, 2005
PubMed
Summary

Schizophrenia patients exhibit working memory (WM) deficits across all tested methods. These working memory impairments are not affected by longer delays, suggesting early processing issues.

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Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Neuroscience

Background:

  • Working memory (WM) deficits are a core cognitive symptom in schizophrenia.
  • Variability in WM assessment methods complicates cross-study comparisons.

Purpose of the Study:

  • To determine if schizophrenia patients have WM deficits across diverse methodologies.
  • To assess if WM deficits in schizophrenia are supramodal.
  • To investigate if WM deficits worsen with increased delay periods.

Main Methods:

  • A meta-analytic review was conducted.
  • Data from studies assessing WM in schizophrenia patients and healthy controls were synthesized.
  • WM performance across different modalities and delay lengths was analyzed.

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Main Results:

  • Significant WM deficits were observed in schizophrenia patients across all examined modalities.
  • The performance difference between schizophrenia patients and controls did not change with delays exceeding 1 second.
  • WM deficits in schizophrenia appear to be modality-independent.

Conclusions:

  • Schizophrenia is associated with a modality-independent working memory deficit.
  • The findings suggest that encoding and/or early maintenance stages of WM may be impaired in schizophrenia.
  • WM deficits in schizophrenia are a robust finding, irrespective of assessment method or delay duration.