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Related Experiment Videos

Development of renal function.

Gerald S Braun1, Stephan M Huber

  • 1Medizinische Poliklinik, Ludwig-Maximilians-Universität München.

Zoology (Jena, Germany)
|December 15, 2005
PubMed
Summary
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Kidney development involves epithelial organogenesis and mesenchymal-to-epithelial transitions. This review details the crucial roles of ion channels in nephrogenesis, ensuring proper kidney function and organ formation.

Area of Science:

  • Developmental Biology
  • Renal Physiology
  • Molecular Biology

Background:

  • Mammalian kidney development follows epithelial organogenesis principles, involving ureteric bud arborization and mesenchymal-to-epithelial transitions.
  • Developing nephron epithelia require functional vectorial transport systems for filtration and metabolite retention, alongside fluid secretion for organ formation.

Purpose of the Study:

  • To review current data and concepts on the development of renal epithelial functions.
  • To emphasize the role of ion channels during kidney development (nephrogenesis).

Main Methods:

  • Review of existing literature on renal epithelial function development.
  • Introduction of model systems: ureteric bud cell monolayer culture, in vitro nephron culture, HEK293 cell culture, and tubular cell dissection.

Related Experiment Videos

  • Analysis of developmental expression and function of specific ion channels.

    • Main Results:

    • Data on the developmental expression and function of key ion channels are presented.
    • Includes epithelial sodium channels (ENaC), cystic fibrosis transmembrane conductance regulator (CFTR), chloride channels (ClC-2), calcium channels (L-type Ca(2+)), purinoceptors (P2), and potassium channels (Kir6.1/SUR2, ROMK, Kv).

    Conclusions:

    • Ion channels play critical roles in both the functional maturation and morphogenic processes of the developing kidney.
    • Understanding these channels is vital for comprehending normal nephrogenesis and potential developmental disorders.