Allograft aortic valve replacement in the adult: a review

Aortic valve replacement using an allograft has been used continuously for over 40 years. Its advantages are excellent haemodynamic function, low thrombogenicity, resistance to infection and avoidance of the complications of anticoagulation. The main concern is its long-term durability, with the high hazard phase for failure between 10 and 20 years. We have only recently been able to judge the true long-term behaviour of the contemporary allograft with two recently published series of patients having reached follow-up beyond 20 years in significant numbers. This review of allograft aortic valve replacement in the adult covers the areas of history, benefits, techniques of sterilisation and preservation, operative methods and outcomes.