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Published on: September 1, 2018
Transferable DHA-1 cephalosporinase in Escherichia coli
P Giakkoupi1, A Tambic-Andrasevic, S Vourli
1Department of Microbiology, National School of Public Health, Athens, Greece.
Abstract:
Three Escherichia coli isolates resistant to third-generation cephalosporins but negative for extended-spectrum beta-lactamase production were isolated from hospitalised patients in Zagreb, Croatia, during June 2003 to February 2004. Resistance was due to the inducible production of a DHA-1 cephalosporinase. Each isolate contained an integron-associated bla(DHA-1)-ampR sequence carried by similar-sized plasmids, of which one was self-transferable. Serotyping and polymerase chain reaction typing using ERIC2 primer indicated that the isolates were distinct. This is the first description of DHA beta-lactamase production in E. coli.
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