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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
[Disturbances of cardiac rhythm and metabolic control in patients with type-2 diabetes]
Insights
Type 2 diabetes patients exhibit more severe arrhythmias, with atrial fibrillation linked to lower HbA1c and high-grade ventricular extrasystoles to higher HbA1c. Ventricular late potentials predict arrhythmias and indicate poor glycemic control in these patients.
Area of Science:
- Cardiology
- Diabetology
- Electrophysiology
Background:
- Type 2 diabetes is associated with increased cardiovascular risk.
- Diabetic patients often present with more complex arrhythmias.
- Glycemic control is a critical factor in managing diabetic complications.
Purpose of the Study:
- To investigate the relationship between type 2 diabetes and arrhythmias.
- To assess the prognostic value of ventricular late potentials in diabetic patients.
- To explore the correlation between glycemic control and specific arrhythmia types.
Main Methods:
- 142 cardiological patients (101 with type 2 diabetes) underwent 24-hour ECG monitoring.
- Ventricular late potentials were registered.
- Glycated hemoglobin (HbA1c) levels were measured.
Main Results:
- Diabetic patients had more severe arrhythmias, including atrial fibrillation and high-grade ventricular extrasystoles (HGVE).
- Atrial fibrillation was more frequent with HbA1c <7%, while HGVE occurred more often with HbA1c >8.5%.
- Ventricular late potentials (QRSTt >110 ms, LAS40 >37 ms, RMS <23 mcV) predicted HGVE and indicated poor glycemic control.
Conclusions:
- Type 2 diabetes is linked to a higher burden of prognostically unfavorable arrhythmias.
- Ventricular late potentials are valuable predictors of HGVE and markers of inadequate glycemic management in diabetic individuals.
- Close monitoring of arrhythmias and glycemic control is essential for managing cardiovascular risk in type 2 diabetes.
Abstract:
Twenty four hour ECG monitoring, registration of ventricular late potentials, and measurement of glycated hemoglobin (HbA1c) were included into examination of 142 cardiological patients (101 with and 41 without type 2 diabetes). Groups of patients with and without diabetes had similar age and severity of cardiac pathology. Patients with diabetes had more prognostically and hemodynamically unfavorable arrhythmias -- paroxysmal and permanent atrial fibrillation, high grade ventricular extrasystoles (HGVE) and their combinations. Atrial fibrillation and HGVE were more often observed in diabetic patients with HbA1c <7 and >8.5%, respectively. Date of registration of ventricular late potentials in patients with diabetes mellitus (QRSTt >110 ms, LAS40 >37 ms, and RMS <23 mcV) possess high informative power not only in prognosis of HGVE but also evidences for bad control of glycemia.
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