Related Experiment Video
Updated: Aug 14, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Synthesis and antiviral evaluation of novel 4'-hydroxymethyl branched thioapiosyl nucleosides
1College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
Abstract:
In this study, we synthesized novel 4'-hydroxymethyl branched thioapiosyl nucleosides. The thioapiosyl sugar moiety was constructed using sequential ozonolysis and reduction. The natural bases (uracil, thymine, cytosine, and adenine) were efficiently coupled using the Vorbrüggen glycosyl condensation procedure (persilyated base and TMSOTf). The antiviral activities of the synthesized compounds were evaluated against HIV-1, HSV-1, HSV-2, and HCMV. Compound 19 showed moderate anti-HIV activity (EC(50) = 19.3 microg/mL) without exhibiting any cytotoxicity up to 100 microM.
Related Concept Videos
Antiviral Nucleoside Inhibitors
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release
Biosynthesis of Nucleic Acids
Subviral Agents
DNA Base Pairing
