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Floating drug delivery systems: a review.

Shweta Arora1, Javed Ali, Alka Ahuja

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. shweta_a3@hotmail.com

AAPS Pharmscitech
|December 16, 2005
PubMed
Summary

This review explores floating drug delivery systems (FDDS), focusing on their mechanisms for gastric retention. It details recent advancements, formulation strategies, and evaluation methods for these pharmaceutical dosage forms.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Floating drug delivery systems (FDDS) offer solutions to challenges in pharmaceutical dosage form development.
  • Gastric retention is crucial for optimizing drug absorption and therapeutic efficacy for certain medications.

Purpose of the Study:

  • To review recent literature on floating drug delivery systems (FDDS).
  • To focus on the mechanisms of floatation for achieving gastric retention.
  • To cover recent developments, formulation, and evaluation of FDDS.

Main Methods:

  • Literature compilation and review.
  • Detailed examination of physiological and formulation variables affecting gastric retention.
  • Summary of in vitro and in vivo evaluation techniques.

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Main Results:

  • Recent developments in single-unit and multiple-unit floating systems are discussed.
  • Classification and formulation aspects of FDDS are comprehensively covered.
  • Various techniques for evaluating FDDS performance and applications are summarized.

Conclusions:

  • Floating drug delivery systems present a viable approach to overcome formulation challenges.
  • Understanding floatation mechanisms and formulation variables is key to effective FDDS design.
  • FDDS have broad applications in improving drug delivery and patient outcomes.