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Probing the immune dysregulation in cutaneous T cell lymphomas

Peter Heald1

  • 1Department of Dermatology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA.

The Journal of Investigative Dermatology
|December 16, 2005
PubMed
Abstract

No abstract available in PubMed .

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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