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Sweet syndrome in two children

Mark D Herron1, Cheryl M Coffin, Sheryll L Vanderhooft

  • 1Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

Pediatric Dermatology
|December 16, 2005
PubMed

Insights

Acute febrile neutrophilic dermatosis (Sweet syndrome) in children can present differently. Corticosteroid treatment showed varied responses and side effects in two pediatric cases.

Area of Science:

  • Pediatric Dermatology
  • Rheumatology

Background:

  • Acute febrile neutrophilic dermatosis, or Sweet syndrome, is a rare inflammatory condition.
  • While typically associated with underlying conditions in adults, pediatric cases are less understood.

Observation:

  • Two pediatric patients, a 9-month-old girl and a 4-year-old boy, presented with Sweet syndrome.
  • Both exhibited characteristic symptoms including fever, leukocytosis, and skin lesions following an infection.

Findings:

  • Neither child showed signs of malignancy or chronic systemic illness.
  • The 4-year-old boy responded well to systemic corticosteroids, while the infant experienced disease flares during tapering.
  • Corticosteroid use led to behavioral changes in the boy and growth retardation in the infant, both resolving upon cessation.

Implications:

  • This case series highlights the variable presentation and treatment response of Sweet syndrome in pediatric patients.
  • It underscores the need for careful monitoring of side effects, such as behavioral changes and growth issues, during corticosteroid therapy in children.
  • Further research is needed to elucidate optimal management strategies for pediatric Sweet syndrome.

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