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Sweet syndrome in two children.

Mark D Herron1, Cheryl M Coffin, Sheryll L Vanderhooft

  • 1Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

Pediatric Dermatology
|December 16, 2005
PubMed
Summary

Acute febrile neutrophilic dermatosis (Sweet syndrome) in children can present differently. Corticosteroid treatment showed varied responses and side effects in two pediatric cases.

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Area of Science:

  • Pediatric Dermatology
  • Rheumatology

Background:

  • Acute febrile neutrophilic dermatosis, or Sweet syndrome, is a rare inflammatory condition.
  • While typically associated with underlying conditions in adults, pediatric cases are less understood.

Observation:

  • Two pediatric patients, a 9-month-old girl and a 4-year-old boy, presented with Sweet syndrome.
  • Both exhibited characteristic symptoms including fever, leukocytosis, and skin lesions following an infection.

Findings:

  • Neither child showed signs of malignancy or chronic systemic illness.
  • The 4-year-old boy responded well to systemic corticosteroids, while the infant experienced disease flares during tapering.
  • Corticosteroid use led to behavioral changes in the boy and growth retardation in the infant, both resolving upon cessation.

Implications:

  • This case series highlights the variable presentation and treatment response of Sweet syndrome in pediatric patients.
  • It underscores the need for careful monitoring of side effects, such as behavioral changes and growth issues, during corticosteroid therapy in children.
  • Further research is needed to elucidate optimal management strategies for pediatric Sweet syndrome.

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