Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toward normative expert systems: Part I. The Pathfinder project.

D E Heckerman1, E J Horvitz, B N Nathwani

  • 1Department of Computer Science, University of California, Los Angeles.

Methods of Information in Medicine
|June 1, 1992
PubMed
Summary

Pathfinder, an expert system for lymph-node disease diagnosis, utilizes probability and decision theory for uncertain medical knowledge. Research explored reasoning paradigms, ultimately returning to probability and decision-based methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.

Nature communications·2014
Same author

Eliciting cytotoxic T-lymphocyte responses from synthetic vectors containing one or two epitopes in a C57BL/6 mouse model using peptide-containing biodegradable microspheres and adjuvants.

Vaccine·2014
Same author

Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins.

British journal of cancer·2013
Same author

Diffuse large B-cell lymphoma: a clinicopathologic analysis of 444 cases classified according to the updated Kiel classification.

Leukemia & lymphoma·2002
Same author

Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project.

Annals of oncology : official journal of the European Society for Medical Oncology·2002
Same author

Hyperplasia of mantle/marginal zone B cells with clear cytoplasm in peripheral lymph nodes. A clinicopathologic study of 35 cases.

American journal of clinical pathology·2001

Area of Science:

  • Medical Informatics
  • Pathology
  • Artificial Intelligence

Background:

  • Expert systems are increasingly used in medicine.
  • Pathology diagnosis, particularly for lymph-node diseases, involves complex, uncertain information.
  • Normative expert systems leverage probability and decision theory for knowledge representation and manipulation.

Purpose of the Study:

  • To describe the Pathfinder expert system for lymph-node disease diagnosis.
  • To detail research into uncertain-reasoning paradigms stimulated by Pathfinder's development.
  • To evaluate and compare different approaches to reasoning under uncertainty in medical diagnosis.

Main Methods:

  • Development of the Pathfinder expert system.
  • Exploration of decision-theoretic methods for uncertain reasoning.

Related Experiment Videos

  • Investigation of non-decision-theoretic methods.
  • Experimental and theoretical analysis of reasoning paradigms.

    • Main Results:

    • Pathfinder demonstrates the application of probability and decision theory in diagnostic expert systems.
    • Limitations were identified in early decision-theoretic approaches.
    • Research led to a refined understanding of reasoning under uncertainty.
    • A return to probability and decision theory-based methods was indicated by results.

    Conclusions:

    • Pathfinder serves as a model for expert systems in pathology.
    • The research highlights the importance of robust reasoning under uncertainty.
    • Probability and decision theory remain foundational for complex medical diagnostic systems.