Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sniffing and spatiotemporal coding in olfaction.

John W Scott1

  • 1Department of Cell Biology, Emory University, 405N Whitehead Biomedical Research Center, 615 Michael Street, Atlanta, GA 30322, USA. johns@cellbio.emory.edu

Chemical Senses
|December 16, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

ACS chemical neuroscience·2026
Same author

Dangerous liaisons: Promiscuous inhibition of CHK1 and AMPK is a lethal affair for cancer cells.

Cell chemical biology·2026
Same author

Hospital-Level Variation in IVC Filter Insertion in Trauma Patients: An Opportunity for a National Appropriateness Quality Improvement Initiative.

Annals of surgery·2026
Same author

Financial Hardship in Surgery.

Annals of surgery·2026
Same author

Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.

Nature communications·2026
Same author

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

A method for assessing approach and avoidance behavior across multiple olfactory stimuli in mice including multivariate hypothesis comparisons.

Chemical senses·2026
Same journal

From Receptors to Behavior: Molecular and Functional Logic of Sensory Coding in the Mouse Accessory Olfactory System.

Chemical senses·2026
Same journal

Vomeronasal sensory input and its social behavioral output.

Chemical senses·2026
Same journal

Reference data for Bayesian adaptive QUEST-based taste recognitions thresholds from pooled individual participant data.

Chemical senses·2026
Same journal

Expression of Calca gene-derived peptides in the murine taste system.

Chemical senses·2026
Same journal

The trigeminal function questionnaire (TriFunQ): a tool for clinical and research use.

Chemical senses·2026
See all related articles

Sniffing alters airflow dynamics and odorant sorption in the nasal cavity. This research explores how airflow changes interact with olfactory receptor expression and sensitivity, impacting odor perception.

Area of Science:

  • Olfactory Neuroscience
  • Respiratory Physiology
  • Chemical Senses

Background:

  • Sniffing significantly impacts nasal airflow velocity and duration.
  • Odorant sorption onto the nasal lining is influenced by airflow dynamics.
  • Olfactory receptor properties correlate with gene expression zones.

Purpose of the Study:

  • To investigate how sniffing-induced airflow changes affect odorant sorption.
  • To understand the interaction between nasal aerodynamics and olfactory receptor expression.
  • To explore the predictability of olfactory responses based on odorant hydrophobicity and receptor placement.

Main Methods:

  • Analysis of airflow dynamics during sniffing.
  • Correlation of olfactory receptor gene expression with nasal cavity shape.

Related Experiment Videos

  • Assessment of odorant sorption based on established principles and experimental data.
  • Predictive modeling of olfactory responses.

    • Main Results:

    • Sniffing generates high-velocity airflow, altering odorant sorption.
    • Olfactory receptor responses in the epithelium and olfactory bulb correlate with odorant hydrophobicity.
    • Receptor expression is strategically placed within the nasal cavity to optimize odorant detection based on aerodynamics.

    Conclusions:

    • Nasal airflow dynamics, influenced by sniffing, play a crucial role in odorant perception.
    • Odorant properties like hydrophobicity and molecular shape, combined with nasal aerodynamics, determine olfactory receptor sensitivity and placement.
    • This study enhances our understanding of the interplay between breathing mechanics and the sense of smell.