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Related Experiment Videos

Heat decreases formoterol delivery.

Richard A Robbins1, Allen R Thomas, Lynda M Proctor

  • 1Pulmonary and Critical Care Medicine, Carl T. Hayden VA Medical Center, 650 East Indian School Rd, Phoenix, AZ 85012, USA. Richard.Robbins2@med.va.gov

Chest
|December 16, 2005
PubMed
Summary

High heat significantly reduces formoterol delivery, impacting medication effectiveness. Caution is advised when mailing, transporting, or storing formoterol due to heat sensitivity.

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Area of Science:

  • Pharmaceutical Science
  • Drug Delivery Systems
  • Environmental Health

Background:

  • Anecdotal reports suggest formoterol may aggregate in mailboxes during summer in Arizona.
  • Heat exposure is a potential factor affecting the stability and delivery of inhaled medications.

Purpose of the Study:

  • To investigate the impact of elevated temperatures on formoterol stability and drug delivery.
  • To compare the heat sensitivity of formoterol with other respiratory medications.

Main Methods:

  • Formoterol capsules were subjected to controlled heating (40-70°C) for varying durations.
  • Drug delivery was quantified by measuring dispensed formoterol weight using a manufacturer-provided device.
  • Tiotropium and fluticasone propionate/salmeterol were tested for comparison.

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Main Results:

  • Heating formoterol capsules caused visible clumping and significant reductions in drug delivery, especially at higher temperatures and longer durations.
  • Decreased delivery was observed at temperatures as low as 40°C for 3 hours, and at 70°C for as little as 30 minutes.
  • Tiotropium and fluticasone propionate/salmeterol showed no significant decrease in delivery after similar heat exposure.

Conclusions:

  • Formoterol delivery is demonstrably reduced by heat exposure.
  • Physiological temperatures encountered in environments like Arizona mailboxes can compromise formoterol efficacy.
  • Recommendations include exercising caution during the mailing, transportation, and storage of formoterol to maintain its therapeutic integrity.