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The role of persistent anticardiolipin antibody as risk factor of ischemic stroke

Suzanna Immanuel1, Astuti Giantini, Rahajuningsih S Dharma

  • 1Department of Clinical Pathology, Faculty of Medicine University of Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta.

Acta Medica Indonesiana
|December 16, 2005
PubMed

Insights

Persistent anti-cardiolipin antibodies IgG (ACA IgG) are a significant risk factor for ischemic stroke. However, neither blood viscosity nor ACA IgM showed a significant association with stroke risk in this study.

Area of Science:

  • Neurology
  • Immunology
  • Cardiovascular Research

Background:

  • Ischemic stroke is a leading cause of disability and mortality worldwide.
  • Identifying novel risk factors for ischemic stroke is crucial for effective prevention strategies.
  • Anti-cardiolipin antibodies (ACA) have been implicated in thrombotic events, but their specific role in ischemic stroke requires further elucidation.

Purpose of the Study:

  • To investigate the association between persistent anti-cardiolipin antibodies (ACA) IgG and IgM and hyperviscosity as potential risk factors for ischemic stroke.
  • To determine the independent contribution of these factors to the risk of ischemic stroke.

Main Methods:

  • A case-control study involving 76 subjects (38 ischemic stroke patients, 38 controls) aged 40-70 years.
  • Blood samples were analyzed for persistent ACA IgM and IgG using ELISA and for blood viscosity using a viscometer.
  • Statistical analysis included chi-square and multivariate logistic regression to assess risk factors.

Main Results:

  • Persistent ACA IgG was found in 25% of ischemic stroke cases versus 2.63% in controls, indicating a significant association (p < 0.05, OR 14.11).
  • No significant differences were observed in blood viscosity (p = 0.740) or persistent ACA IgM (p = 1.000) between the case and control groups.
  • Multivariate analysis confirmed persistent ACA IgG as an independent risk factor for ischemic stroke.

Conclusions:

  • Persistent ACA IgG is a significant risk factor for ischemic stroke.
  • Blood viscosity and persistent ACA IgM were not found to be significant risk factors for ischemic stroke in this study population.
  • These findings highlight the importance of ACA IgG testing in the risk assessment of ischemic stroke.
Abstract

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