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Related Experiment Videos

Fungal allergies: a yet unsolved problem.

Reto Crameri1, Michael Weichel, Sabine Flückiger

  • 1Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland. crameri@siaf.unizh.ch

Chemical Immunology and Allergy
|December 16, 2005
PubMed
Summary

Airborne fungal spores cause respiratory allergies like asthma. New recombinant fungal allergens offer improved diagnosis and potential therapies for fungal allergy by identifying specific allergenic components.

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Area of Science:

  • Allergen immunotherapy
  • Molecular allergology
  • Respiratory immunology

Background:

  • Airborne fungal spores are linked to respiratory allergies, including asthma.
  • Prevalence of fungal sensitization is unclear due to non-standardized extracts and numerous fungal species.
  • Fungal sensitization may lead to auto-reactivity via molecular mimicry and shared epitopes.

Purpose of the Study:

  • To explore the role of fungal allergens in respiratory diseases.
  • To investigate the potential of recombinant fungal allergens in diagnosis and therapy.
  • To address the challenge of assessing the clinical relevance of fungal allergens.

Main Methods:

  • High-throughput cloning of fungal allergens.
  • Structural and immunological studies of fungal allergens.

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  • Analysis of molecular mimicry in allergic diseases.

    • Main Results:

    • Fungi produce complex repertoires of species-specific and cross-reactive allergens.
    • Molecular mimicry between fungal and self-antigens contributes to chronic allergic diseases.
    • Standardized single components for diagnosis are feasible, unlike current immunotherapy.

    Conclusions:

    • Recombinant fungal allergens present new opportunities for diagnosing and treating fungal allergy.
    • Accurate diagnosis requires assessing the clinical relevance of individual fungal allergen structures.
    • Future research should focus on developing targeted therapies using specific fungal components.