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Recurrent pancreatitis in a patient with autosomal-dominant polycystic kidney disease

Omer Başar1, Mehmet Ibiş, Engin Uçar

  • 1Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. basaromer@hotmail.com

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|December 16, 2005
PubMed

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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