Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

From angiogenesis to neuropathology.

David A Greenberg1, Kunlin Jin

  • 1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA. dgreenberg@buckinstitute.org

Nature
|December 16, 2005
PubMed
Summary

New blood vessel growth (angiogenesis) is vital for brain development and disease defense. Understanding angiogenesis factors like vascular endothelial growth factor offers potential for new therapies targeting neurodegenerative diseases and stroke.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anacardic acid mitigates traumatic brain injury-induced inflammatory damage: involvement of TLR4/MyD88/NF-κB pathway regulation and inhibition of P300 HAT activity on NF-κB acetylation.

International immunopharmacology·2026
Same author

Biological Age Should Anchor Age-Related Disease Research.

Aging and disease·2026
Same author

Beyond Amyloid: Rethinking the Foundations of Alzheimer's Disease Pathogenesis and Therapy.

Aging and disease·2025
Same author

Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

Adenosine A<sub>2A</sub> Receptor in the Choroid Plexus Modulates Ischemia-Reperfusion Injury in the Cortex.

Journal of the American Heart Association·2025
Same author

Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway.

Journal of neuroinflammation·2025

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Pathophysiology

Background:

  • Angiogenesis, the formation of new blood vessels, is essential for nervous system development and protection.
  • Recent research has advanced the understanding of blood vessel growth in the brain under normal and disease states.

Purpose of the Study:

  • To explore the multifaceted roles of angiogenesis in the nervous system.
  • To highlight the involvement of angiogenesis factors in neurogenesis, neuroprotection, and neurological diseases.

Main Methods:

  • Review of recent advances in angiogenesis research.
  • Analysis of the role of vascular endothelial growth factor (VEGF) in neural processes and diseases.

Main Results:

  • Angiogenesis factors, particularly VEGF, are implicated in neurogenesis and neuroprotection.
  • These factors also play a role in the development of stroke, Alzheimer's disease, and motor neuron disease.

Conclusions:

  • Enhanced understanding of angiogenesis pathophysiology provides a basis for novel therapeutic strategies.
  • Future molecular and cell-based therapies may leverage angiogenesis pathways for treating neurological disorders.

Related Experiment Videos