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Mechanism of Angiogenesis

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Development of Blood Vessels

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Updated: Jun 25, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Angiogenesis as a therapeutic target.

Napoleone Ferrara¹, Robert S Kerbel

¹Genentech, 1 DNA Way, South San Francisco, California 94080, USA. nf@gene.com

|December 16, 2005

Summary

Inhibiting angiogenesis offers a promising cancer and age-related macular degeneration treatment. Further understanding of vascular morphogenesis is crucial for advancing therapeutic angiogenesis in cardiovascular medicine.

Area of Science:

Biomedical science
Cardiovascular medicine
Oncology

Background:

Angiogenesis, the formation of new blood vessels, is a critical process in both physiological and pathological conditions.
Inhibiting angiogenesis is a validated therapeutic strategy for cancers and age-related macular degeneration.
Therapeutic angiogenesis aims to promote blood vessel growth for treating ischemic disorders.

Purpose of the Study:

To summarize the progress in anti-angiogenic therapies.
To highlight the potential of therapeutic angiogenesis.
To identify the need for further research into vascular morphogenesis.

Main Methods:

Review of recent advancements in anti-angiogenic drug development.
Analysis of approved anti-angiogenic agents.

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Discussion of the mechanisms underlying vascular morphogenesis.

Main Results:

Significant progress has been made in developing anti-angiogenic treatments.
Several anti-angiogenic agents have received regulatory approval.
Understanding vascular morphogenesis is key to developing new therapies.

Conclusions:

Inhibiting angiogenesis is a successful strategy for treating specific diseases.
Therapeutic angiogenesis presents a promising future for cardiovascular medicine.
Continued research into the fundamental mechanisms of blood vessel formation is essential.