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Related Experiment Videos

Interactions between ciprofloxacin and antacids--dissolution and adsorption studies.

M Saeed Arayne1, Najma Sultana, Fida Hussain

  • 1Department of Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan. arayne@chemist.com

Drug Metabolism and Drug Interactions
|December 17, 2005
PubMed
Summary

Ciprofloxacin absorption is significantly reduced when co-administered with common antacids. This interaction can lead to therapeutic failure, highlighting the importance of careful medication timing.

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Area of Science:

  • Pharmacology
  • Drug Interactions
  • Pharmaceutical Sciences

Background:

  • Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic, is widely prescribed for bacterial infections.
  • Concurrent administration with antacids can alter ciprofloxacin's absorption, potentially causing treatment failure.

Purpose of the Study:

  • To investigate the impact of various antacids on the dissolution and availability of ciprofloxacin.
  • To assess the interaction between ciprofloxacin and common antacids used in polytherapy.

Main Methods:

  • Dissolution studies of ciprofloxacin tablets were performed using the BP 2002 apparatus.
  • Experiments were conducted in simulated gastric and intestinal fluids at 37°C for 3 hours.
  • The influence of specific antacids including sodium bicarbonate, calcium hydroxide, calcium carbonate, aluminum hydroxide, magnesium hydroxide, magnesium carbonate, magnesium trisilicate, and magaldrate was evaluated.

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Main Results:

  • All tested antacids significantly retarded the dissolution rate of ciprofloxacin tablets.
  • Magaldrate and calcium carbonate showed high adsorption in simulated gastric juice.
  • Magnesium trisilicate and calcium hydroxide demonstrated significant adsorption in simulated intestinal juice.

Conclusions:

  • Co-administration of ciprofloxacin with common antacids negatively impacts its dissolution and potentially its bioavailability.
  • Specific antacids like magaldrate, calcium carbonate, magnesium trisilicate, and calcium hydroxide exhibit notable adsorption characteristics.
  • Clinical recommendations should consider the timing of ciprofloxacin and antacid administration to prevent reduced efficacy.