Related Experiment Video
Updated: Aug 14, 2026
Two-Photon Laser-Mediated Ablation of Osteoblasts in Developing Zebrafish Larvae
Published on: September 6, 2024
XeCl excimer laser ablation of rabbit tibia bone: morphology of the irradiated site and self-limiting effect
Tercio Obara1, Egberto Munin, Edson A Libert
1Instituto de Pesquisa & Desenvolvimento (IPD), Universidade do Vale do Paraíba, UNIVAP, São José dos Campos, SP, Brazil.
Objective:
The purpose of this work is to investigate the morphological changes of the rabbit tibia bone submitted to osteotomy with XeCl excimer laser.
Background Data:
Laser ablation of tissue is a relevant clinical application of high-power lasers. Due to the variety of laser wavelengths and properties of biological targets, the subject has not yet been completely explored.
Methods:
In this study, four tibias were irradiated with six different durations. The applied energy density was 6.7 J/cm(2) per pulse at a 4-Hz repetition rate.
Results:
The 24 samples had similar and well-defined craters that were free of carbonization. The ablation rates per pulse, at 60-120 seconds, were 3.8 and 1.9 microm at the compact bone and the marrow tissue, respectively. The ablation process ceased after 120 sec, with a 1.6-mm crater depth.
Conclusions:
In the present study, the laser used showed a self-limiting characteristic, which is a phenomenon that can be of great value in preserving important structures close to the working area, giving a margin of safety to the surgeon, in case of over-irradiation. This self-limiting effect is attributed to liquid filling the cavity by the bleeding and irrigation process.
More Related Videos
09:51One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
05:10Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025