Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemoglobin and flow-mediated vasodilation.

Per Lav Madsen1, Michaela Scheuermann Freestone, Stefan Neubauer

  • 1University Laboratory of Physiology and the Department of Cardiovascular Medicine, University of Oxford, UK. Fyrrevang11@dadlnet.dk

Clinical Science (London, England : 1979)
|December 17, 2005
PubMed
Summary

Low hemoglobin concentration is linked to vasodilation through nitric oxide (NO) absorption. This study found that lower hemoglobin levels correlated with increased flow-mediated vasodilation (FMD) in normal subjects, suggesting a compensatory mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an optimised method for the analysis of human blood plasma samples by atmospheric solids analysis probe mass spectrometry.

International journal of mass spectrometry·2026
Same author

Dietary Medium-Chain Triacylglycerols Preserve Cardiac Function During High-Fat Feeding and Improve Ketolysis Capacity in Mice.

JACC. Heart failure·2026
Same author

Improving the diagnostic performance of troponin assays for acute myocardial infarction in renal impairment.

Heart (British Cardiac Society)·2026
Same author

The Effect of Empagliflozin on Left Ventricular Mass and Volumes in Older Adult Individuals With Overweight and High Risk of Heart Failure: The Empire Prevent Cardiac Trial.

Journal of cardiac failure·2026
Same author

Changes in absolute coronary blood flow and myocardial resistance after percutaneous coronary intervention.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

Effects of empagliflozin in patients at risk of heart failure: the Empire Prevent Metabolic Trial.

European journal of preventive cardiology·2026

Area of Science:

  • Cardiovascular Physiology
  • Vascular Biology
  • Endocrinology

Background:

  • Low hemoglobin concentration (Hb) is associated with peripheral vasodilation through incompletely understood mechanisms.
  • Nitric oxide (NO) released from vascular endothelium influences vasodilation; Hb absorbs NO, limiting its bioactivity.
  • A proposed mechanism suggests graded NO absorption mediates the relationship between low Hb and vasodilation.

Purpose of the Study:

  • To investigate the relationship between Hb concentration and flow-mediated vasodilation (FMD) in radial and brachial arteries.
  • To compare FMD in normal subjects and patients with Type II diabetes, who have impaired NO-mediated vasodilation.
  • To determine if radial artery FMD is a more sensitive measure of vasodilation.

Main Methods:

Related Experiment Videos

  • Assessed FMD using cuff ischemia in 33 normal subjects and 13 diabetic patients.
  • Measured FMD in both radial and brachial arteries.
  • Correlated FMD measurements with Hb concentration.

    • Main Results:

    • The radial artery exhibited significantly larger FMD than the brachial artery in normal subjects (22% vs. 9%).
    • Radial artery FMD showed a negative correlation with Hb concentration (r²=-0.66, P<0.05) in normal subjects.
    • In normal subjects, lower Hb levels (<14.1 g/dl) were associated with higher radial artery FMD (30%) compared to higher Hb levels (13%).
    • Diabetic patients had lower FMD, and no correlation with Hb concentration was found.

    Conclusions:

    • In normal individuals, NO-mediated vasodilation partially compensates for the effects of low Hb concentration during post-ischemic reperfusion.
    • The radial artery serves as a more sensitive indicator for assessing flow-mediated vasodilation.
    • Impaired NO-mediated vasodilation in diabetes may disrupt the compensatory relationship between Hb levels and vasodilation.