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Updated: Jun 28, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Alpha-peptide/beta-sulfonamidopeptide hybrids: analogs of the chemotactic agent for-Met-Leu-Phe-OMe
Cesare Giordano1, Gino Lucente, Annalisa Masi
1Dipartimento di Studi farmaceutici, Università di Roma La Sapienza and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, P.le A. Moro 5, 00185 Roma, Italy. cesare.giordano@uniroma1.it
Abstract:
In order to gain information on the activity shown by alpha-peptide/beta-sulfonamidopeptide hybrid analogs of the potent chemotactic agent fMLF-OMe, a structure-activity study is reported on N-Boc- and N-formyl tripeptide models containing an aminoalkanesulfonic acid as central residue. Directed migration (chemotaxis), superoxide anion production, and lysozyme release have been measured. The biochemical functions and the conformational properties of the new compounds are discussed and related to previously studied models containing beta-residues.
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