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Related Experiment Videos

Aggressive fibromatosis: MRI features with pathologic correlation.

Justin C Lee1, J Meirion Thomas, Simon Phillips

  • 1Department of Radiology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England.

AJR. American Journal of Roentgenology
|December 17, 2005
PubMed
Summary

MRI can help diagnose aggressive fibromatosis (desmoid tumors). Imaging features on MRI correlate with pathology, but MRI and pathology findings do not predict recurrence after surgery.

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Area of Science:

  • Radiology
  • Oncology
  • Pathology

Background:

  • Aggressive fibromatosis, also known as desmoid tumors, are rare neoplasms.
  • Accurate diagnosis and staging are crucial for treatment and prognosis.

Purpose of the Study:

  • To correlate MRI features with histopathologic findings in aggressive fibromatosis.
  • To evaluate the diagnostic and prognostic implications of MRI in aggressive fibromatosis.

Main Methods:

  • Retrospective review of imaging (MRI) and histopathologic data from 60 patients.
  • Analysis of 29 preoperative MRI scans with confirmed aggressive fibromatosis diagnosis.

Main Results:

  • Average age at diagnosis was 41.3 years; female-to-male ratio 1.2:1.

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  • Lesions varied in location (extraabdominal, intraabdominal, abdominal wall) and size (average 6.4 cm).
  • MRI showed characteristic signal intensities and avid enhancement; however, some features previously considered diagnostic were absent in a significant portion of cases. Recurrent disease was associated with higher recurrence rates post-surgery, but MRI and pathology did not predict this.

    • Conclusions:

    • MRI is valuable for diagnosing and staging aggressive fibromatosis.
    • Understanding MRI features aids in patient management and predicting outcomes, although recurrence prediction remains challenging.