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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
Gene expression determinants of clinical outcome
1Department of Pathology and Microbiology, The South Carolina Cancer Center, Division of Basic Research, The University of South Carolina, School of Medicine, Columbia, South Carolina 29229, USA. phillipb@gw.med.sc.edu
Current Opinion in Oncology
|December 17, 2005
Summary
Gene expression signatures offer insights into cancer
Area of Science:
- Oncology
- Molecular Pathology
- Bioinformatics
Background:
- Gene expression profiling generates substantial data for cancer treatment decisions.
- Studies have identified gene expression patterns linked to neoplasm appearance and behavior.
Purpose of the Study:
- To review emerging trends in study design for gene expression signature identification.
- To discuss recently discovered gene expression signatures correlating with cancer characteristics.
Main Methods:
- Review of current literature on gene expression profiling in human cancers.
- Analysis of study designs and identification approaches for gene expression signatures.
Main Results:
- Gene expression signatures correlate with cellular morphology and chemotherapy resistance.
- Identified signatures are associated with the overall clinical course of various neoplasms.
Conclusions:
- Prospective evaluation of gene signature predictive value is warranted.
- Independent validation of newly discovered gene signatures is essential.
- Timely reporting of validation results, both positive and negative, is crucial for molecular pathology advancement.
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