Related Experiment Video
Updated: Aug 14, 2026

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
Published on: November 9, 2017
Basic science for the clinician 34: Interleukins of current clinical relevance (part II)
1Pharmaceutical Research Institute/Bristol-Myers Squibb, J. 3100, PO Box 4000, Princeton, NJ 08543-4000, USA. leonard.sigal@bms.com
Abstract:
As you saw in the first part of this description of interleukins, normal orchestration of wound healing, the protective immune response and inflammation involves many cells that must effectively communicate with each other. The means of this communication is often soluble messengers (cytokine) and many of them bear the title interleukin. Although all these messengers have a role in normal immune homeostasis, it is apparent that many are involved in tissue damage in a variety of disease, eg, rheumatoid arthritis, osteoarthritis. I dealt with interleukins (IL) 3 to 16 in the first part of this project. We now pick up the story with IL-17. Turns out, much of the most exciting recent work in rheumatology has focused on IL-17 and IL-18. The disparate effects of the interleukins may be confusing, often a single cytokine producing multiple effects seemingly at crossed purposes, but we are in our infancy when it comes to insights into the molecular biology of normal immune function, homeostasis, inflammation, and disease.
Related Concept Videos
Acute Inflammation II: Cellular Phase
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease II: Ulcerative Colitis
The JAK-STAT Signaling Pathway
Acute Inflammation III: Local and Systemic Effects
