Unusually high alkaline phosphatase due to intestinal isoenzyme in a healthy adult
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Updated: Aug 14, 2026

Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence
Published on: July 5, 2021
Sung R Cho1, Young A Lim, Wee G Lee
1Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Republic of Korea. sungran@ajou.ac.kr
Abstract:
Intestinal alkaline phosphatase (ALP) is more prevalent in individuals of blood group O or B, and increases after a meal, especially on a high-fat diet. We did not realize that clinicians could underestimate the importance of fasting for ALP measurement until one healthy adult showed a huge difference in ALP levels before and after a meal. We report a case of transient hyperphosphatasemia resulting in unnecessary workup due to intestinal ALP in a healthy adult of blood group O.
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