Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using animals in research, testing and teaching.

C Gauthier1, G Griffin

  • 1Executive Director, Canadian Council on Animal Care, 1510-130 Albert, Ottawa ON K1P 5G4, Canada.

Revue Scientifique Et Technique (International Office of Epizootics)
|December 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Widespread service fragmentation for patients and families with tuberous sclerosis complex (TSC) in the Republic of Ireland.

Journal of rare diseases (Berlin, Germany)·2024
Same author

Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.

Journal of internal medicine·2020
Same author

The Efficacy and Tolerability of Levetiracetam as a First Line Monotherapy in Childhood Epilepsy.

Irish medical journal·2020
Same author

[Switching and stopping antidepressants].

L'Encephale·2018
Same author

A novel interferometric method for the study of the viscoelastic properties of ultra-thin polymer films determined from nanobubble inflation.

The Review of scientific instruments·2017
Same author

Assessing and regulating homeopathic products.

Journal of internal medicine·2017
Same journal

Foreword - The World Organisation for Animal Health turns 100: reflections on the Organisation's role and evolution since 1924.

Revue scientifique et technique (International Office of Epizootics)·2024
Same journal

Preface - World Organisation for Animal Health: one hundred years at the service of animal health.

Revue scientifique et technique (International Office of Epizootics)·2024
Same journal

An appreciation of the seminal contributions of John Brooksby and Fred Brown on foot and mouth disease.

Revue scientifique et technique (International Office of Epizootics)·2024
Same journal

Are the knowledge, tools and resources to control foot and mouth disease available?

Revue scientifique et technique (International Office of Epizootics)·2024
Same journal

Rinderpest and peste des petits ruminants: a century of progress and the future.

Revue scientifique et technique (International Office of Epizootics)·2024
Same journal

Rinderpest and peste des petits ruminants: state of play in disease eradication efforts.

Revue scientifique et technique (International Office of Epizootics)·2024
See all related articles

This study reviews ethical standards in animal research, highlighting the 3Rs (reduction, replacement, refinement) as a unifying principle. It shows progress in reducing animal use and calls for international harmonization of ethical guidelines.

Area of Science:

  • Ethical considerations in scientific research
  • Animal welfare in research settings
  • Regulatory science and policy

Background:

  • Historical overview of animal-based research landmarks.
  • Examination of moral statements guiding animal use in science.
  • Introduction of the 3Rs (Reduction, Replacement, Refinement) as a core ethical framework.

Purpose of the Study:

  • To review progress in replacing animal use with non-animal methods, particularly in regulatory testing.
  • To present evidence of reduced animal numbers in scientific research during the 1990s.
  • To emphasize the need for international harmonization of ethical standards and processes in animal research.

Main Methods:

  • Review of scientific literature and regulatory testing data.

Related Experiment Videos

  • Analysis of trends in animal usage statistics.
  • Examination of techniques for pain and distress mitigation in animal models.
  • Assessment of the role of institutional Animal Care Committees.

    • Main Results:

    • Evidence of progress in the replacement of animal use with non-animal alternatives.
    • Demonstrated reduction in the number of animals used in research during the 1990s.
    • Identification of factors contributing to potential increases in animal use (e.g., genetic modification, regulatory demands).
    • Emphasis on refinement techniques, including appropriate endpoints, to minimize animal suffering.

    Conclusions:

    • The 3Rs framework offers a common ground for animal welfare and scientific communities.
    • Continued efforts are needed to prevent an escalation in animal use figures.
    • International harmonization of ethical standards and processes is crucial.
    • Institutional Animal Care Committees play a vital role in overseeing ethical animal research.