Related Experiment Video
Updated: Aug 14, 2026
Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
Published on: March 24, 2023
[Evaluation of cochlear function in children with chronic renal failure]
Agata Hajduk1, Grazyna Lisowska, Grzegorz Namysłowski
1Katedra i Oddział Kliniczny Laryngologii w Zabrzu, SLAM w Katowicach.
Insights
Chronic renal failure (CRF) in children can impair cochlear function, as shown by significantly lower distortion product otoacoustic emissions (DPOAEs) compared to healthy peers. This study identifies optimal DPOAE parameters for clinical assessment in these patients.
Area of Science:
- Otoacoustic emissions
- Pediatric audiology
- Nephrology
Context:
- Chronic renal failure (CRF) affects multiple organ systems, including the auditory system.
- Early detection of cochlear dysfunction in pediatric CRF is crucial for timely intervention.
- Distortion product otoacoustic emissions (DPOAEs) offer a non-invasive method for assessing outer hair cell function.
Purpose:
- To objectively assess cochlear function in children with CRF using DPOAEs.
- To establish optimal ipsilateral stimulation parameters for DPOAE measurements (DP-gram format) in a clinical setting.
- To compare DPOAE results between children with CRF and healthy controls.
Summary:
- Hearing acuity was evaluated in 19 children with CRF and 18 healthy children.
- Pure tone audiometry and tympanometry were performed; only participants with normal middle ear function and hearing thresholds better than 30 dB HL proceeded.
- Significantly lower mean DPOAE amplitudes were observed in CRF children across all measured frequencies compared to controls.
- Optimal DP-gram parameters for clinical use were identified as specific L1 and L2 levels (e.g., 65/60 dB SPL, 63/55 dB SPL, 59/45 dB SPL).
Impact:
- Highlights the subclinical auditory pathway involvement in pediatric CRF.
- Provides evidence for using DPOAEs as a sensitive tool for monitoring cochlear health in CRF.
- Establishes practical DPOAE measurement protocols for clinical application in pediatric nephrology and audiology settings.
Unlabelled:
In present study cochlear function was evaluate in young chronic renal failure (CRF) patients using distortion product otoacoustic emissions (DPOAEs).
The Aim Of Study:
(a) objective assessment of cochlear function in CRF children, (b) establishing best parameters of ipsilateral stimulation in DPOAEs (DP-gram format) for clinical use. Hearing acuity was assessed in 19 CRF children and 18 healthy children. At first pure tone audiometry and tympanometry were evaluate. Only patients with normal middle ear condition and hearing threshold better than 30 dB HL were put forward further investigations. Objective assessment of cochlear function included DPOAEs using DP-gram format. Our results reviled significantly lower mean DPOAE amplitudes in CRF children when compare to healthy children, at all frequencies measured. Most optimal DP-gram parameters in clinical use seems to be level L1 and L2 equal respectively: 65 and 60 dB SPL; 63 and 55 dB SPL; 59 and 45 dB SPL.
