Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Timolol in lipospheres.

M R Gasco1, R Cavalli, M E Carlotti

  • 1Dipartimento di Scienza e Tecnologia, Farmaco Università di Torino, Italy.

Die Pharmazie
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variability on the energy properties of charcoal and charcoal briquettes for barbecue.

Heliyon·2022
Same author

A case of onychomadesis associated with chilblain-like lesions after COVID-19 infection.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Treatment of children from 6 to 11 years old affected by moderate-severe atopic dermatitis with dupilumab: a first perspective from a single-center real-life experience in Italy.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Effective energy exploitation from horse manure combustion.

Waste management (New York, N.Y.)·2021
Same author

A mathematical model for the evaluation of iron transport across the blood-cerebrospinal fluid barrier in neurodegenerative diseases.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Incorporation of Cró thermal water in a dermocosmetic formulation: cytotoxicity effects, characterization and stability studies and efficacy evaluation.

International journal of cosmetic science·2019
Same journal

Effectiveness of the Clinical Decision Support System Upgrade in the Automated Unit Dose Drug Dispensing System.

Die Pharmazie·2026
Same journal

Guggulsterone Alleviates Atherosclerosis in ApoE<sup>-/-</sup> Mice by Modulating Lipid Metabolism and Inflammatory Responses Associated with Modulation of the <i>Srebp2</i>/<i>Hmgcr</i> Signaling Axis.

Die Pharmazie·2026
Same journal

Postmarketing Safety Concerns With Caplacizumab: A Real-World Pharmacovigilance Study Based on the FDA Adverse Event Reporting System Database.

Die Pharmazie·2026
Same journal

Ferulenol, a Prenylated Coumarin, Suppresses Collagen-Induced Platelet Activation via PLCγ2-Mediated cPLA2 Signaling in Humans.

Die Pharmazie·2026
Same journal

Assessment of the Quality of Finished Intravenous Infusions Using Failure Mode and Effects Analysis.

Die Pharmazie·2026
Same journal

Clinical and Biochemical Determinants of the Systemic Inflammation Response Index During Vancomycin Therapy.

Die Pharmazie·2026
See all related articles

Lipospheres encapsulating timolol were developed using microemulsions for enhanced drug delivery. Formulation differences, particularly ion pair lipophilicity, significantly impacted timolol incorporation into these novel nanocarriers.

Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Drug Delivery

Background:

  • Timolol is a beta-blocker used to treat glaucoma.
  • Developing effective drug delivery systems is crucial for improving therapeutic outcomes.
  • Lipospheres offer potential for controlled and targeted drug release.

Purpose of the Study:

  • To develop and characterize lipospheres loaded with timolol.
  • To investigate the influence of microemulsion composition on timolol incorporation.
  • To understand the role of ion pair formation in enhancing timolol lipophilicity and incorporation.

Main Methods:

  • Lipospheres were prepared using microemulsion techniques.
  • Key constituents included lecithin, palmitic acid, and decanoic acid.

Related Experiment Videos

  • Particle size analysis was performed.
  • Timolol content and its form (ion pairs) within lipospheres were analyzed.

    • Main Results:

    • Lipospheres with sizes ranging from 300 to 400 nm were successfully obtained.
    • Timolol incorporation varied between 2.7% and 4.8% depending on the microemulsion formulation.
    • Timolol was primarily incorporated as lipophilic ion pairs.
    • The lipophilicity of these ion pairs was the main factor influencing incorporation efficiency.

    Conclusions:

    • Microemulsion-derived lipospheres are a viable system for carrying timolol.
    • Optimizing ion pair lipophilicity is key to maximizing timolol loading in lipospheres.
    • This approach enhances the potential for improved timolol delivery systems.