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Published on: August 13, 2019
Procoagulant state after raloxifene therapy in postmenopausal women
George Dantas Azevedo1, Rendrik França Franco, Márcia Sueli Baggio
1Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP, Brazil. georgedantas@uol.com.br
Objective:
To investigate the effects of raloxifene on the hemostatic system in postmenopausal women.
Design:
A prospective longitudinal study.
Setting:
Outpatient clinic of the Faculty of Medicine of Ribeirão Preto, Brazil.
Patient(S):
Sixteen postmenopausal women aged 56.8 +/- 5.9 years (mean +/- SD).
Intervention(S):
Raloxifene hydrochloride (60 mg once daily) was administered orally for a period of 6 months.
Main Outcome Measure(S):
Plasma activities of coagulation factors (II, V, VII, VIII, IX, X, XI, XII, and fibrinogen), prothrombin-derived fragment 1+2, and activated protein C (APC) sensitivity ratio were measured at baseline and after 1, 3, and 6 months of treatment.
Result(S):
Factor VIII activity increased by 17.1% and 26.9% at 3 and 6 months of treatment, respectively, compared with baseline. Factor XI and FXII activities significantly increased by 10.9% and 43.1%, respectively, after 6 months compared with baseline. A significant reduction of APC sensitivity ratio also was observed after 6 months of treatment.
Conclusion(S):
A procoagulant state characterized by increased factor VIII, XI, and XII plasma levels and by reduced APC sensitivity was observed after raloxifene therapy in post-menopausal women.
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