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Related Experiment Videos

Why should we care about CARE-HF?

Kenneth A Ellenbogen1, Mark A Wood, Helmut U Klein

  • 1Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. kaellenb@vcu.edu

Journal of the American College of Cardiology
|December 20, 2005
PubMed
Summary

Cardiac resynchronization therapy (CRT) significantly reduces mortality and hospitalizations in heart failure patients with ventricular dyssynchrony. CRT also improves heart remodeling and function over time.

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Area of Science:

  • Cardiology
  • Heart Failure Management
  • Device Therapy

Background:

  • Previous trials indicated short-term benefits of cardiac resynchronization therapy (CRT).
  • The impact of CRT on long-term morbidity and mortality remained less defined.

Purpose of the Study:

  • To evaluate the definitive impact of CRT on mortality and morbidity in heart failure.
  • To assess the effect of CRT on ventricular remodeling and myocardial performance.

Main Methods:

  • Analysis of data from the Cardiac Resynchronization-Heart Failure (CARE-HF) study.
  • Comparison of CRT with optimal medical therapy, including CRT with defibrillation.

Main Results:

  • CRT significantly reduced mortality by 36% (p < 0.002) in NYHA class III/IV heart failure with dyssynchrony.

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  • CRT demonstrated progressive reversal of ventricular remodeling and improved myocardial performance for at least 18 months.
  • Combined data from CARE-HF and COMPANION trials show CRT significantly reduces mortality and hospitalizations compared to optimal medical therapy.

    • Conclusions:

    • CRT is unequivocally beneficial for reducing mortality and hospitalizations in select heart failure patients.
    • Adding an implantable cardioverter-defibrillator to CRT offers additional survival benefits, particularly reducing sudden cardiac death.