Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related differences in heparin response.

Vera Ignjatovic1, Janine Furmedge, Fiona Newall

  • 1Department of Haematology, Royal Children's Hospital, Flemington Road, Parkville 3052, Victoria, Australia. verai@unimelb.edu.au

Thrombosis Research
|December 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ACAT3 controls hepatic cholesterol metabolism and modulates systemic energy homeostasis of male mice.

Life sciences·2026
Same author

Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia.

Blood·2026
Same author

A method for visual psychophysics based on the navigational behavior of desert ants (Melophorus bagoti).

Journal of experimental psychology. Animal learning and cognition·2026
Same author

A qualitative study exploring the pros and cons of universal pediatric palliative care referral at diagnosis for children with cancer.

Palliative & supportive care·2026
Same author

Systematic review on the design and methodology of the pediatric direct oral anticoagulant clinical trials for thrombosis prevention: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Nocturnal ants navigate using a time-compensated lunar compass.

Current biology : CB·2026
Same journal

Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition.

Thrombosis research·2026
Same journal

Heatstroke-induced coagulopathy: A scoping review of therapeutic strategies and outcome reporting.

Thrombosis research·2026
Same journal

Mapping thrombus habitat: Non-contrast MRI radiomics and pixel-tile histomics approach to track venous thrombosis evolution in mice.

Thrombosis research·2026
Same journal

A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study.

Thrombosis research·2026
Same journal

Associating the phenotypic expression of platelets with disease type through image-based single-cell profiling.

Thrombosis research·2026
Same journal

The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions.

Thrombosis research·2026
See all related articles

Heparin

Area of Science:

  • Pediatric Coagulation
  • Pharmacology
  • Clinical Chemistry

Background:

  • Pediatric coagulation differs significantly from adults.
  • The effect of these differences on heparin anticoagulant therapy is not well understood.

Purpose of the Study:

  • To investigate age-related variations in heparin's anticoagulant effects.
  • To determine if age-specific therapeutic ranges for heparin are necessary.

Main Methods:

  • Collected plasma from healthy children and adults, creating age-specific pools.
  • Spiked plasma with heparin and measured activated Partial Thromboplastin Time (APTT), Anti-Factor Xa, and Anti-Factor IIa activity.
  • Analyzed results from three independent plasma pool experiments.

Main Results:

Related Experiment Videos

  • Significant age-related differences in APTT were observed for equivalent Anti-Factor Xa heparin concentrations.
  • Younger children showed higher APTT values at the same Anti-Factor Xa level.
  • Heparin's Anti-Factor IIa activity varied with age for a given Anti-Factor Xa activity.

Conclusions:

  • Age significantly impacts heparin's anticoagulant effect as measured by APTT.
  • Current heparin dosing assumptions may not be universally applicable to pediatric patients.
  • Consideration of age-specific therapeutic ranges for heparin in children is recommended.