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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
Transfusion-related acute lung injury
Christopher C Silliman1, Nathan J D McLaughlin
1Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA. christopher.silliman@uchsc.edu
Blood Reviews
|December 20, 2005
Summary
Transfusion-related acute lung injury (TRALI) is a severe transfusion reaction and leading cause of transfusion death. Understanding its antibody-mediated and two-event models is key to prevention and treatment.
Area of Science:
- Hematology
- Immunology
- Critical Care Medicine
Background:
- Transfusion-related acute lung injury (TRALI) is a critical transfusion complication with rising incidence.
- TRALI is the primary cause of transfusion-related mortality in the United States.
- TRALI shares clinical definitions with acute lung injury (ALI) but is specifically linked to blood product transfusions.
Purpose of the Study:
- To elucidate the pathogenesis of TRALI.
- To discuss proposed models explaining TRALI development.
- To examine TRALI definition, predisposition, treatment, and prevention strategies.
Main Methods:
- Review of proposed pathogenetic models for TRALI.
- Discussion of antibody-mediated and two-event hypotheses.
- Analysis of supporting animal models and human studies.
Main Results:
- Two primary pathogenetic models for TRALI are presented: antibody-mediated and a two-event model.
- The antibody-mediated model involves antibody-antigen interactions activating neutrophils.
- The two-event model includes patient conditions and transfusion of biologic modifiers activating neutrophils.
Conclusions:
- TRALI pathogenesis involves complex immune and inflammatory responses.
- Understanding these mechanisms is crucial for clinical management.
- Further examination of TRALI definition, patient factors, and guidelines is warranted.
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