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Effect of prostatic massage on serum complexed prostate-specific antigen levels
Fatih Tarhan1, Asuman Orçun, Inci Küçükercan
1Urology Clinic, Kartal Training and Research Hospital, Istanbul, Turkey. tarhanf@yahoo.com
Urology
|December 20, 2005
Summary
Prostatic massage minimally increased serum complexed PSA (cPSA) levels, with greater increases observed in total PSA (tPSA) and free PSA (fPSA). Chronic prostatitis showed a more significant rise in all PSA forms after massage.
Area of Science:
- Urology
- Andrology
- Biochemistry
Background:
- Prostate-specific antigen (PSA) is crucial in diagnosing prostate conditions.
- The impact of prostatic massage on various PSA forms requires clarification.
- Complexed PSA (cPSA) is a specific biomarker for prostate cancer detection.
Purpose of the Study:
- To investigate the effect of prostatic massage on serum cPSA levels.
- To compare changes in cPSA with total PSA (tPSA) and free PSA (fPSA) after massage.
- To analyze these effects across different prostatic diseases.
Main Methods:
- 51 men with lower urinary outflow obstruction symptoms were enrolled.
- Serum PSA levels (tPSA, fPSA, cPSA) were measured pre- and post-prostatic massage.
- Chemiluminescent enzyme immunoassay was used for PSA quantification.
Main Results:
- Prostatic massage significantly increased tPSA, fPSA, and the fPSA/tPSA ratio (P < 0.0001).
- A minimal but statistically significant increase in cPSA was observed (P = 0.047).
- Patients with chronic prostatitis exhibited greater increases in all PSA forms compared to prostate cancer patients.
Conclusions:
- Prostatic massage elevates serum cPSA, though less than tPSA and fPSA.
- PSA levels, particularly cPSA, are influenced by prostatic massage.
- Findings suggest careful consideration of prostatic massage prior to PSA testing in clinical practice.