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Predictive factors for the histologic response to preoperative radiotherapy in advanced oral cancer
Kojiro Onizawa1, Hiroshi Yoshida, Kiyoshi Ohara
1Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. k-oni@md.tsukuba.ac.jp
Purpose:
Preoperative radiotherapy and chemotherapy are important in treating advanced oral cancer. We attempted to elucidate predictive factors for the histologic response to preoperative radiotherapy or chemoradiotherapy.
Patients And Methods:
Forty-three patients with locally advanced cancer of the oral cavity and oropharynx were treated preoperatively with radiotherapy (50 Gy); surgery included modification of the resected area to preserve organ function.
Results:
Hemoglobin level and histologic differentiation were independent factors significantly associated with the histologic response by multivariate analysis. Locoregional failure occurred only in patients with poor histologic response, and there was a significant difference in the 5-year survival rate between patients with good and poor responses (84% vs 32%). Multivariate analysis indicated that the histologic response at the primary site and the number of metastatic lymph nodes were prognostic factors.
Conclusion:
We identified predictive factors for a good response to preoperative therapy and found a high survival rate in patients with a good response.