Related Experiment Video
Updated: Aug 14, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
Normal clotting
Theresa A Moran1, Carol S Viele
1Division of Physiologic Nursing, University of California San Francisco Medical Center 94143, USA. moran.theresa@ucsfmedicalcenter.org
Objective:
To review the normal coagulation process and the mechanisms that lead to abnormal clotting.
Data Sources:
Primary and tertiary literature and the authors' clinical experience.
Conclusion:
The process of coagulation is complex and can be easily misunderstood. It is important to be familiar with normal coagulation before one can comprehend the coagulopathies associated with malignancies.
Implications For Nursing Practice:
A thorough understanding of the coagulation process is a critical prerequisite to caring for patients with clotting disorders. Once the normal clotting process is understood, the abnormal becomes easier to recognize and the cancer-associated dysfunctions more readily identified.
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