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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Progress in the control of hepatitis B infection in the Western Pacific Region
C John Clements1, Yang Baoping, Alan Crouch
1Centre for International Health, The Macfarlane Burnet Institute for Medical Research and Public Health Ltd., GPO Box 2284, Commercial Road, Melbourne, Vic. 3004, Australia. john@clem.com.au
Insights
Hepatitis B vaccination is widespread in the Western Pacific Region, but challenges like timely birth doses and vaccine affordability hinder full protection for children against Hepatitis B virus (HBV) infection.
Area of Science:
- Public Health
- Vaccinology
- Infectious Disease Epidemiology
Background:
- Hepatitis B virus (HBV) infection poses a significant global health burden, disproportionately affecting the Western Pacific Region.
- Hepatitis B vaccine was integrated into all immunization programs in the Region by 2001.
- Despite progress, challenges persist in achieving universal protection for newborns against HBV.
Purpose of the Study:
- To assess the progress of hepatitis B control strategies in the Western Pacific Region.
- To evaluate the effectiveness of the Expanded Programme on Immunization in reducing chronic HBV infection.
- To identify remaining challenges in achieving high vaccination coverage for hepatitis B.
Main Methods:
- Analysis of hepatitis B control strategies and progress in the Western Pacific Region.
- Review of coverage data for the three-dose hepatitis B vaccine regimen.
- Assessment of national immunization programs' capacity to reach all children.
Main Results:
- Significant progress has been made in hepatitis B control through immunization in the Region.
- However, some national programs struggle to reach all children with immunization services.
- Challenges include delivering timely birth doses and ensuring vaccine affordability.
Conclusions:
- While immunization efforts have advanced hepatitis B control, universal protection remains a goal.
- Addressing challenges in vaccine delivery, timeliness, and cost is crucial for future success.
- Continued efforts are needed to strengthen national programs and ensure equitable access to hepatitis B vaccination.
Abstract:
Hepatitis B virus infection is a serious problem globally, and particularly in the Western Pacific Region where the population suffers disproportionately from the infection and its sequelae. By 2001, every immunization programme in the Region had included hepatitis B vaccine in their schedule. However, many challenges remain if every one of the 26 million children born in the 37 countries and areas of the Region each year is to be protected against hepatitis B infection. In 2003, the Regional Committee of the World Health Organization's Western Pacific Region resolved to improve hepatitis B control by making it one of two new pillars for strengthening the Expanded Programme on Immunization. The Committee endorsed the strategies of the Regional Plan to improve hepatitis B control through immunization, reducing chronic HBV infection (chronic carriage rate) to less than 1%, and aiming for coverage of at least 80% of the birth cohort in every district with three doses of hepatitis B vaccine by 2005. To help guide this process, an assessment was made of the progress to date, and is reported in this paper. Coverage data used in this evaluation were not independently verified, and could over-estimate progress made in some countries. Whilst there has indeed been great progress in the Region, a number of national programmes still lack the ability to reach all children with immunization services. Other major issues that need to be addressed are the challenges of delivering a timely birth dose, and for certain countries, the affordability of the vaccine over the short- and long-term.
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