Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular pathways mediating mechanical signaling in bone.

Janet Rubin1, Clinton Rubin, Christopher Rae Jacobs

  • 1Department of Medicine, VAMC and Emory University School of Medicine, Atlanta GA, VAMC-151, 1670 Clairmont Rd, Decatur, GA 30033, USA. janet.rubin@emory.edu

Gene
|December 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel mutation in <i>FN1</i> causing spondylometaphyseal dysplasia corner fracture type in a multigenerational family.

JCEM case reports·2026
Same author

Mesenchymal stem cells differentiate dynamic from static load through variable regulation of the Hippo pathway.

Journal of biomechanics·2026
Same author

Author Correction: Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis.

Communications biology·2025
Same author

Concerns about the paper, "Benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial".

JBMR plus·2025
Same author

Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain.

bioRxiv : the preprint server for biology·2025
Same author

Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis.

Communications biology·2025

Bone adapts its structure to mechanical forces, involving specialized cells and molecular pathways. Understanding these mechanotransduction processes is key to improving bone health through interventions like exercise.

Area of Science:

  • Biomechanical Engineering
  • Cell Biology
  • Skeletal Physiology

Background:

  • Bone tissue exhibits remarkable adaptability to mechanical loading, optimizing its structure for functional demands.
  • The skeleton's adaptive capacity raises fundamental biological questions regarding mechanical signal sensing, transduction, and cellular responses.

Purpose of the Study:

  • To review the mechanical factors influencing bone, the cells that sense these forces, and the molecular mechanisms involved.
  • To explore the mechanoreceptors and intracellular signaling pathways activated by mechanical stimuli in bone.

Main Methods:

  • Review of literature on mechanical factors (strain, stress, pressure) in the skeleton.
  • Analysis of mechanosensitive cells (osteoblasts, osteoclasts, osteocytes, vascular cells).

Related Experiment Videos

  • Examination of potential mechanoreceptors (ion channels, integrins, connexins, lipid rafts) and downstream signaling pathways (G-proteins, MAPKs, nitric oxide).

    • Main Results:

    • Identifies key mechanical factors and mechanosensitive cells in bone adaptation.
    • Discusses various candidates for mechanotransduction receptors and their mechanisms.
    • Outlines intracellular signaling cascades initiated by mechanical stimuli.

    Conclusions:

    • Mechanical loading is a critical regulator of bone structure and efficacy.
    • Further exploration of mechanotransduction pathways holds promise for enhancing bone health interventions.